Bonjour Anna,

I would say it depends (obviously) very much on your personal tastes.  Apparently and surprisingly  there is no English version of the whole program...

However, some activities are scheduled in Englsih : look at the section on the right handside on the third page for details.

https://www.ville-ge.ch/culture/nuitdesmusees/docs/ndm18_programme.pdf

It says :    Activities in English   and   Activities suitable for English speakers. 

Many thanks for the quote from the link but can’t help wondering if there may be some activities that are unsuitable for anglophones – and at night-time   too.

Vivre la différence!  

As Chris correctly points out, there is no english version of the complete program, but you can find the activities that will be conducted in English through this link:

https://www.ville-ge.ch/culture/nuitdesmusees/english_programm.html#?inEnglish=true&hdcp=false

It is pretty much what is listed in the 3rd page of the pdf of the complete program, with a few more details.

It does not help you find out which of the many other activities in French will be of interest to you.