I went to Prague in 2011 when I was last in Geneva.

The first decision I made was to just fly there. Weekends away are too short to waste on travel time. I booked at the Novotel - it's called Wenceslas Square but don't be fooled, it's not actually in Wenceslas Square. It's fairly standard hotel, no real charm, but the price was good and it was clean. Everything is definitely in walking distance.

I used the Prague tourism site (http://www.praguewelcome.cz/en/) before I arrived. One of the good things on there are suggested itineraries for 1, 2 or 3 days which at least make sure you take in the main sites.

When I got to the airport, I just took the normal public bus in to the main train station. You buy the tickets in the arrivals hall at the airport, they are much cheaper than any other alternative and you get to see Prague's suburbs on the way in.

I love walking, so I didn't use any other transport options really - but I did take a ride on their metro just to see what it was like!

I'll let you explore the tourism websites for information about sites. My only real tip is to hang around the Old Town Sqaure on the Saturday night. When I was there, there was some sort of festival on - lots of food and wine stalls, a stage with free concerts and even some pole dancers!

My photos from Prague are here: http://www.flickr.com/photos/anura/tags/prague/show/

DO:

Charles bridge, old town + palace, old town square, wenceslas square, narrow streets between old town square and charles bridge.

If you have time, and excursion to Karlstejn castle (see picture).

Eat traditional Czech food called Gulash with Knedliki (bread dumplings)

Visit medieval czech pubs (can't remember names)

Drink Czech beer

See a puppet show

Go to the museum at the top of Wenceslas square (only if you have time, not top priority)

DON'T

Hang around the central station; it's an unpleasant place.

(Don't) walk through the town by yourself unless you're fine with being approached by prostitutes at every street corner. 

Eat at a touristy restaurant. (e.g. at Wenceslas square or old town square). Look up places online and if necessary book them in advance. 5-minute effort but the difference in quality (and price) is dramatic.

Note: I meant mala strana + palace (i.e. at the other side of the river). 

Let me do all that homeowrk and then I'll update this forum.

Thanks a lot for your information! :)

Thanks for this, Edward. Should be very handy.

Walking through the town by myself - Me and my buddy (another guy) plan to walk a lot. I am sure they would not disturb tourists who are in the city for a walking tour. I am also wondring how bad can it be.

I'll also follow your advice for booking things early. I prefer it that way. No hassles later.

Noted. Thanks, again!

Funny. I saw plenty of prostitutes but was never approached. Not sure what that says about me...

My wife is coming to Geneva this time, so we will make another trip to Prague. Karlstejn castle looks fantastic - definitely on the next trip.

Another great find was in the church across the Charles Bridge on the way to the cathedral. If you climb to the top (inside the dome), there is a museum on the spying activities of the old Communist Government. The church used to be a secret spying base, and there are lots of great photos taken from there.

Dont forget to visit the graveyard, there is something special about it, cant remember what. And those free classical street concerts. Prague is great.

Do:

Yes, the Old Jewish Cemetery (closed on Saturdays) - it's magic. If you don't find it at a first glance: it's above your heads. Not a Do, rather a Must, I'd say.

Don't:

From my experience: go to Prague on a summer weekend (even worse: during summer holidays) as it's absolutely overcrowded.

However: enjoy your trip!!

Do (if you have time to cover all the places) :): 

Recommended restaurants:

Graveyard! Interesting.. :D

I'm sure you'll have a great time there as it's a cool city but just a couple of bits of advice: Don't take any taxis if you can avoid it. Their idea of a straight line varies massively from yours and mine. Especially don't take any taxis for any real distance as you'll see fares that would make a Geneva taxi driver feel sick!

Also from what I remember, always check the price of wine in restuarants. For a cheap bottle of red which is akin to something you'd pick up in Aldi's, you could pay an astromonical amount.

Otherwise, 'bav se dobre'!